Everyone needs some stress in their lives to function. However, long term stress can have long-term detrimental effects.
Chronic Stress and Chronic Disease
Stress has been linked to inflammation and chronic disease. A recent study conducted by Carnegie Mellon University found that prolonged stress can lead to a wide range of diseases. They tested the impact of chronic stress on the glucocorticoid receptor resistance. The glucocorticoid receptor functions in almost every cell in the body and controls the immune response. The study found that chronic stress resulted in glucocorticoid receptor’s failure to down-regulate the inflammatory response. The study concluded:
“These data provide support for a model suggesting that prolonged stressors result in (glucocorticoid receptor resistance) GCR, which, in turn, interferes with appropriate regulation of inflammation. Because inflammation plays an important role in the onset and progression of a wide range of diseases, this model may have broad implications for understanding the role of stress in health.”
276 healthy adults were exposed to the common cold virus and quarantined and monitored five days. Signs of infection were measured.
In a second group, 79 participants were assessed for their ability to regulate the inflammatory response and then exposed to a cold virus (rhinovirus) and monitored for the production of pro-inflammatory cytokines. Cytokines are the chemical messengers that trigger inflammation. The findings indicated that those who were less able to regulate the inflammatory response as assessed before being exposed to the virus produced more of these inflammation-inducing chemical messengers when they were infected.
Researcher Dr Cohn stated in an interview with Science Daily
“The immune system’s ability to regulate inflammation predicts who will develop a cold, but more importantly it provides an explanation of how stress can promote disease,” Cohen said. “When under stress, cells of the immune system are unable to respond to hormonal control, and consequently, produce levels of inflammation that promote disease. Because inflammation plays a role in many diseases such as cardiovascular, asthma and autoimmune disorders, this model suggests why stress impacts them as well.”
He added, “Knowing this is important for identifying which diseases may be influenced by stress and for preventing disease in chronically stressed people.”